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18F-FET (18F-fluoro-ethyl-tyrosine, Fluoroethyl-L-tyrosine (18F) injection)
18F-fluoro-ethyl-tyrosine (18F-FET) is an artificial amino acid taken up into upregulated tumoral cells but not incorporated into proteins.
18F-FET PET has shown value in the diagnosis of brain tumor recurrence after initial surgery or radiotherapy and for directing biopsy or radiosurgery (Dunet.V. et al. Nucl Med February 1, 2012 vol. 53 no. 2 207-21)
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Test |
Technic/instrument |
|
Appearance |
Visual |
|
Radionuclidic Identity |
Gamma-ray spectroscopy with Multichannel analyser |
|
Radionuclidic Identity |
Half-life determination with a dose calibrator |
|
pH |
pH-meter or pH strips with reading through a reflexion photometer |
|
Chemical purity (Fluoroethyl-L-tyrosine and related substances) |
Gradient HPLC with UV detector |
|
Impurtiy kryptofix (aminopolyether) |
Spot test |
|
Residual solvents and ethanol |
Gas chromatography |
|
Bacterial endotoxins (LAL) |
Endosafe Portable Test System (PTS) |
|
Radiochemical purity |
Radio-HPLC |
|
Radiochemical purity and 18F-fluoride |
Radio-TLC |
|
Radiochemical identity |
Radio-HPLC |
|
Osmolality |
Osmometer |
|
Radionuclidic purity |
Gamma-ray spectroscopy with Multichannel analyser |
|
Sterility |
Compendial method |
|
Radioactivity |
Dose calibrator |